Another Cyclodextrin Innovation from Hungary!
RotaChrom Technologies, a global player in Centrifugal Partition Chromatography (CPC), published research on scalable enantioseparation of rac-voriconazole.
Key Innovation
- Batch CPC baseline intensified to cyclic continuous stacked-injection CPC
- MDM CPC mode enables continuous injection and dual-outlet product collection
- MDM CPC intensification delivers approximately 25× productivity gain versus resolution
- Continuous CPC reduces solvent and selector use through repeated phase recycling
Cyclodextrin Swap
The research replaced the more expensive sulfobutyl ether-β-cyclodextrin (SBE-β-CD) with lower-cost randomly methylated β-cyclodextrin (RM-β-CD) without compromising the partitioning and selectivity required for MDM operation.
Results
Continuous MDM CPC produced (2R,3S)-voriconazole achieving ≥99.8% optical purity and 99.9% enantiomeric excess, with 81% isolated yield.
Contributors: Anita Kiss, Dóra Rutterschmid, and Szabolcs Muráth.
