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Some applications require more than commercially available cyclodextrins. New drug delivery systems, targeted delivery concepts, gene and nucleic acid delivery, cyclodextrin-based active ingredients, vaccine adjuvants, diagnostics, environmental technologies, and advanced materials can all benefit from cyclodextrins designed specifically for their intended function. CarboHyde provides world-class, industry-focused expertise in the design, synthesis and development of novel cyclodextrins and cyclodextrin-based technologies.Our work starts with the application, not simply with the chemistry. When designing a new cyclodextrin, we simultaneously consider performance, synthetic feasibility, scalability, cost, patentability, safety and regulatory acceptability. This helps avoid technically interesting molecules that later become impractical because they are too complex to manufacture, too expensive to scale, difficult to characterize, or unsuitable for the intended regulatory pathway.
We develop unique cyclodextrins for a broad range of pharmaceutical and non-pharmaceutical applications. Examples include functionalized and amphiphilic cyclodextrins for gene and nucleic acid delivery, targeted drug delivery systems, cyclodextrin-based APIs, novel excipients, vaccine adjuvant concepts and molecular recognition systems.
Beyond pharmaceuticals, cyclodextrin chemistry can provide powerful platforms for environmental remediation, selective capture and detection of pollutants such as PFAS, sensors, separation technologies, advanced materials and other molecular-recognition applications. In these projects, the chemical structure of the cyclodextrin can be tailored to introduce specific binding, charge, hydrophobicity, targeting functionality, reactivity or material properties required by the final application.
CarboHyde can support the complete development pathway from initial molecular concept to a reproducible and scalable process. We perform route scouting, laboratory-scale synthesis, reaction optimization, purification development, impurity profiling, analytical method development and full structural characterization. Once a promising candidate has been identified, we optimize the process with scalability, robustness, yield, raw-material availability and manufacturing economics in mind.Our development programs can also include structure–activity relationship studies, candidate library synthesis, specification development, stability testing and safety-oriented characterization. Because novel cyclodextrins can represent valuable proprietary technology, we also work closely with clients on IP strategy, generation of supporting experimental data and development of patentable chemical space, compositions and manufacturing processes.
A novel cyclodextrin only becomes commercially meaningful if it can ultimately be manufactured reproducibly and at the required quality. CarboHyde therefore develops chemistry with the final manufacturing process in mind from the beginning. Laboratory procedures can be progressively optimized, scaled and transferred to larger production, while analytical controls and specifications evolve alongside the process.Our support can extend from milligram- and gram-scale discovery work through process development, scale-up, technology transfer, regulatory and CMC support, and implementation into GMP manufacturing. The objective is to create not just a new cyclodextrin molecule, but a technically differentiated, patentable, economically realistic and industrially executable product or platform.
